Possible side effects of Sinemet

Consumer Information (MedFacts)

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; mental or mood changes; muscle pain or unusual stiffness; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unexplained fever or sweating; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred/double vision); yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

Advanced Consumer Information (Micromedex)

You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.

• restless muscle movements in your eyes, tongue, jaw, or neck;

• worsening of tremors (uncontrolled shaking);

• fever, stiff muscles, confusion, sweating, fast heart rate, rapid breathing;

• seizure (convulsions);

• severe nausea, vomiting, or diarrhea;

• uneven heart rate or fluttering in your chest;

• confusion, agitation, unusual thoughts or behavior; or

• depressed mood, thoughts of suicide or hurting yourself.

Less serious side effects may include:

• nausea, loss of appetite;

• diarrhea, constipation, upset stomach;

• headache, dizziness, drowsiness;

• nightmares, increased dreaming;

• numbness or tingly feeling;

• muscle pain; or

• skin rash or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Consumer Information (Cerner Multum)

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

This medicine may sometimes cause the urine, saliva, and sweat to be darker in color than usual. The urine may at first be reddish, then turn to nearly black after being exposed to air. Some bathroom cleaning products will produce a similar effect when in contact with urine containing this medicine. This is to be expected during treatment with this medicine. Also, this medicine may cause a bitter taste, or a burning sensation of the tongue.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.